Our Suprasetter 74 with full automation was installed in February 2007, and we have had very few problems. The speed of the machine is what we expected with two lasers, and if we want more, we'll pay for more. In its current configuration, it stays WAY ahead of the presses.
In our experience, plate load problems are almost always caused by plates that are bent or dogeared in the cassette, and the machine does recover well and on its own. Yes, the error correction time seems lengthy at times, but nothing reboots fast enough when you're waiting for it.
One of the biggest reasons we stayed with Heidelberg and bought a Supra (which replaced a Prosetter 74) was the ability to run plates manually should the automation fail. This happened earlier this year, in fact, but all we had to do was lift the cover to the online processor bridge and manually feed plates until the autoloader was repaired. The competitors machines that we shopped didn't have this option.