I know of a couple estimating software systems. EFI has a few flavors Presswise is kind of a complete workflow pricing thing for digital. and there has been a few 3 party that look to be okay. I would do a search and go from there
I agree with Craig. Morningflight has come a long way with their latest update.
They now offer tiered click charges, wide format, and very good default pricing. If you need high dollar MIS software there are more robust alternatives out there. But this certainly fills a void in the marketplace for those of us on a budget.