No... The mechanical aspects of the DC5000 and the DC250, etc are similar in the xerographic areas, but it is designed for the older, oil-requiring toner that is used in the 2060/6060/8000, etc. Even though the cartridges are the same, the toner loaded in them is TOTALLY INCOMPATIBLE... (Since the DC5000 is an oil-based fuser, and the other a dry fuser.) If you're looking to get DC5000 toner cheaper, buy 2060/6060 toners and transpose it. I had a DC5000 for a while (until I got totally sick and tired of the oil fuser) and I actually switched to the 7002/8002 MATTE toner and it produces a stunningly beautiful silken finish on the DC5000... (The DC5000's real toner is a little too glossy for my taste for most projects.)