It's a paper humidity issue. I just replied to this exact same issue on another forum. I've run into it on a variety of stocks before. It has nothing to do with the press humidity, it has everything to do with the climate where the paper is stored.
As an example, here's our most recent encounter with this issue: We occasionally print on Mohawk Ultra Gloss C1S 10pt. As we don't run it much, we've had a partial ream open for a while now. I ended up getting a job that would use this stock, so I ordered a couple more reams. I wanted to run the open stock first, but the first print showed this exact same speckling/mottling issue. We opened up a new ream and voila...beautiful prints. So what changed if we had been running the open ream just fine until now? A while back I moved the open ream from our pressroom to our bulk storage area where the climate is a bit different - it's more of a warehouse area, whereas our pressroom is more of an office area with better climate control.
99% of the time, when I pull paper from our bulk storage area and immediately run it - there are no problems...but occasionally there is a paper that shows this issue. It's either an open ream or a partial bulk carton - both of which we haven't run for a little while.
I have seen this issue on our previous Konica C1060 and our current C3080. I usually just run from a different box/ream if I see this issue, and then bring the affected papers into our pressroom to acclimate over a few days.