15-20 percent plate gain seems bizarre from a CTP device, something is definitely wrong with how it is set up. I'm guessing you are running your ink densities low to compensate for the huge gain on the plates, that is probably why you are having ink fluctuations and a flat image as it's throwing your ink and water balance on press out, too little ink.
I think you need your CTP machine calibrated properly, if you get your plates back to linear then you can look at applying a standard SWOP or Gracol plate curve and get good results running normal ink densities.
There might be an independent service provider in your area or you could look at contacting the original equipment company to see if they have a tech near where you guys are.