There's good discussion here - I hope this answers the various questions posed (but you can always contact me with more);
First, regarding press sheet sizes that are smaller than Thermal Direct plates: during the start up of the press, the oscillation of the ink rollers migrate the ultrathin coating to the center of the rollers enabling the make-ready sheets to completely remove the coating of the non imaged area from the press. We have many customers doing this. The worst case scenario is you might have to do a blanket cleaning, depending on your press - something easy to test for with a set of demo plates that we'll gladly provide. The amount of coating interacting with the ink rollers is probably not much more than the dissolved coating that's retained in the gum left on Azura plates at the end of the gum bath life - and without the green dye.
Regarding reading plates: Thermal Direct plates have an image contrast distinct enough to easily read 12 pt. type for cylinder identification. The emulsion is a blue-green-gray color, and is also visible in yellow light (which you normally wouldn't want in your pressroom anyways) . With the fact that you are removing process variation by not having to use a processor - especially if you also have Kodak's rock-solid SQUAREspot imaging system - Thermal Direct customers have the confidence to go on press without measuring the plate. What comes out of the CTP system is what will print on press.
The concern surrounding putting Thermal Direct on a multi-million dollar press is based on FUD (fear, uncertainty, and doubt) created by our competitors, plus the failures of earlier DOP technologies. Thermal Direct has never had a single report of press contamination - even with press sheets that are smaller than the plate. Again the ultra-thin coating of the non imaged area is able to removed from the press without contamination and then perform like any other litho plate. The real question is why wouldn’t you take advantage of a technology to remove the costs and variables of processing or "cleaning out" a plate? Even a "clean out unit" has considerable costs on an annual basis - capital costs, maintenance, chemistry, cleaning, disposal, energy, and footprint.