A single in register form roller on its own is not sufficient to prevent mechanical ghosting. For the single form roller concept that is used in Anicolor, Karat, etc. the ink film on the form roller is not uniform everywhere. The non coverage areas on the form roller has a thicker ink film than the image areas. With this concept, the roller that supplies ink to the form roller MUST have a uniform ink film everywhere. That is why an anilox roller is used. The intention is to uniformly ink the image areas of the single form roller.
If you supplied an in register single form roller with a conventional roller train set up, it would not be very difficult to uniformly ink the image area. Also mechanical ghosting patterns could come back onto the single form roller, in image areas, from the supply roller.
There are other ways to use a single form roller concept but it would not have to be an in register concept. With a not in register concept, the ink film on the single form roller MUST be uniform. This would result in no mechanical ghosting. This can be approached in different ways.
The multi form roller design is probably a result of tradition and rule of thumb design as anything. It worked well enough and as long as printer bought it, why should the press manufacturers change. Customer demands in performance will have an affect on technology development. If you don't complain there will be no change.
The devil is in the details of any approach taken. One can not just change one thing and expect a positive change. With roller trains, everything affects ever other thing.