Yeah its do-able, but yeah you need a good operator! I know plenty of places that never had 4 col presses and didnt farm out 4 col work, and did a good job of it....dont know if they are still around... You will need a good 2 col press, a speedy, a GTO, or a ryobi with a well trained operator, and there are plenty of other capable machines out there, these are just the ones i have experience with, and pullin 4 colour work or 5 or 6 colour and coated was easy enough just time consuming! The last company i worked with had a 512h ryobi that we were able to pull great jobs off with very little drama. A before mentioned a densitometer will help, but a good eye for colour will help more!! Keep plenty of run ups to settle colour down on make readies, and everything that billy has touched on is spot on...