Just some questions that I can think of off the top of my head.
1) What kind of volume to you intend to put on it (average pages per month)?
Duty Cycle and recommended monthly volume
This will dictate whether you need a small light-production/office class press, a mid-range medium production press, or a high-volume large production press.
2) How fast do you need to print them?
Again, will determine the one of the three category of presses above.
3) What kind of things will you be printing? (major applications)
Will you need to print up to 350 gsm (up to 16-point card stock) or will you just be printing booklets & flyers?
Does this press need to be able to print envelopes?
If printing saddle-stitched booklets, do you need an inline booklet-maker?
If printing post cards or business cards, tight registration will be needed. Typically, light or office class production will not have tight registration.
High Quality Color Consistency for photograph books, art reproduction, etc., or "good-enough" color for direct mail.
4) Are you an in-plant operation, or, are you print for pay?
If you are an in-plant, your deadline dates on production usually aren't as stringent as if you are print for pay.
If your are print for pay, like us, then service and minimal down time are crucial.
5) What's your budget?
Office/Light Production class is least expensive. Mid-range medium production class is more expensive than light/office class. High Volume is most expensive.
I'm not going to discuss actual pricing, as this is frowned upon on this forum, but, the range across those 3 categories is around $20,000 USD on the low end,
to as high as $1.2 million on the high end. I never advocate actual machine "purchases", but, strongly suggest machine "leases" instead for various reasons
(you can research other posts on this forum about that subject).
"And when you get to the point when you've narrowed it down to a smaller group of presses that you feel fit your business needs, how do you make the final decision?"
Set up a demo of the final machines that you are looking at. Bring you're own art and paper and then see which one does the best job for your application, and, which ones you are most comfortable running. Ask about how many service technicians they have operating in your area, how big their territory is, parts availability, and service response times. After you have it narrowed down, NEGOTIATE, the deal with as low a click charge as you can get, but, lock it in over the life of the lease.
Good Hunting!
-MailGuru