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"Best customers" are always the ones who pay.
I have worked in many shops and I have seen really good customers in one shop that would be a worst possible fit in another.
It really depends on what you are set up to do... if you're set up as a small copy shop and don't care to expand or don't have the acumen and capital, you don't need or want Gallo; if you run a 40" perfector, you don't need or want the chapel down the street.
This, incidentally, is the bugaboo of many printing salespeople.
There are salespeople who work at cross purposes from their shop: they bring in work that the shop is just not going to make money on, but everyone from management on down thinks that the salesperson should still be paid and praised for it. (Kind of like the cat that brings a dead lizard into the house.)
They do this because their contacts are not compatible with the goals of the shop. A salesperson will rarely want to jettison "perfectly good" contacts to develop unknown opportunities. If all his contacts are small construction firms, he won't pitch them even if his company is most profitable (and highly competitive) at annual reports for Fortune 500 companies.
Selection of salespeople is an oft neglected art in hiring. You don't have to hire a salesperson with great numbers if his clients aren't going to be profitable for your operation. Even if they ARE profitable for other shops.
And of course this leads to my public service announcement that trade printers can rescue retail printers in situations like this. Usually, retail printers will buy things that are "above" their capabilities... it's also a good idea to consider having a trade source who can produce work "beneath" your capabilities, too.