It can be simple or complicated, it depends. Because of the procedure of Apogee licensing it is recomended to contact your local Agfa service. Some configuration parameters are available after switching to Service Mode which needs password.
If you get platesetter and software with configured computer you can start after connecting all cables (and yellow dongle), but configuration of plate sizes, output formats and other things can be needed... it also depends on Apogee version (2.0, 2.11, 2.5, 3.0, 3.5, 4.0 next versions concerns Apogee Prepress not ApogeeX) and type (light, prime, commercial etc). You also need to modify Palladio configuration using engine panel according to Apogee plate configuration.