Predictability and consistency are two sides of the same coin--the somewhat less stable output of this type of press. There is both short-cycle and longer-cycle color drift. Other than machine maintenance there is little you can do about the former; consider it the noise floor of the system. Longer-cycle drift can be addressed, of course, but some methods are better than others. Curve adjustments at the press computer have the disadvantage of messy housekeeping, which you've alluded to. The correction is for dot gain or loss, and by extension gray balance and contrast. Anything more, for example, a change in overprints as a consequence of a substrate change, would not be addressed effectively. For that a "3D" reprofiling would be better, and much is gained by keeping operators out of the curve tools. EXP05 is a good preset--you can leave it there and profile the press.
GRACoL CRPC6 is actually mostly in-gamut for an Indigo with CMYK inks printing on coated paper, so it is in fact a reasonable target for normalization of files destined for printing on similar substrates. CRPC3 is a good general-purpose reference for uncoated stocks. The output profile, assuming you're color-managing, is whatever the press profile is made on the selected substrate for the job at hand. So, this means fixed curves, a profiled press with profile set as output in the DFE our color server, and some means of updating the press profile as color drifts. If the procedure takes longer tan 5 or 6 minutes you can be pretty sure the operators will avoid it, as they have work to get out.
Once this reasoning is accepted you need to consider the quality of the color conversions. A number of third-party tools are available, though they differ greatly in capabilities in handling complex PDFs, and this includes not just image quality but also spot color conversions, transparencies, and many other tricky matters.
We haven't discussed spot color conversions, per se, but matching spot colors actually absorbs the greatest amount of operator time in a label shop, as variances in these colors are immediately noticed. Accurate press profiles are essential, but so is a rational method for characterizing these colors, and for most operators this means, wrongly, specific device values (e.g., CMYK) rather than colorimetric ones. Another handicap is the failure to exploit the extra Indichrome OGV primaries when needed to make the match. The usual reason given is the impact on press speeds and click charges, but just as important is the failure to understand management of multicolor spaces. This is not part of standard operator training.
I've tried to keep my comments general because these are the prerequisite ideas for understanding the problem. If you need more specific guidance you can find me offline.
Best of luck,
Mike Strickler
MSP Graphic Services