I think your question breaks into two parts: retouching, and accurate output. I personally treat it just as I do when retouching in RGB for a CMYK final.
Since Gamma 2.2, or Dot Gain 20%, etc. are just idealised working spaces, the choice has more to do with the performance of that space for your work than anything else. I personally use Gamma 2.2 and 16bit* for all my grayscale work. Although you could get the same result with a different curve in another space, I find that when curving in the Gamma 2.2 space I use more "organic" curve shapes to better effect (the distribution/re-distribution of tones along the scale obviously varies in different spaces).
Ultimately, after flattening, I convert to 8bit and to a CMYK "rich black" or black only profile based on the output condition. I'll generally do perceptual conversions for grayscale work.
If you're aiming to retouch directly in the best choice of output space, the answers would be different.
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* I use 8bit for colour, since I've proven to myself that there's rarely an advantage to 16bit with multiple-channel images, but for single channel images like grayscales, 256 steps isn't enough.