First off, be easy on the spray powder. Is the peice heavy coverage? If not, go a little easier on the powder. That stuff can ruin parts of your digital. I did this a few years back when I was running a Xerox 5000. We ran blanks on press and then imprinted on the digi. All that powder gets into the sensors and the paper dust traps, and also sticks to the transfer belt and the fuser parts. As for the curl: I don't know what machine you are running, but you might have a decurler. I have a decurling feature on my machine and it works well. It's a little difficult to figure out at first, but once you do, you'll love it.
I also run VD on my Xerox. I don't run the high quantities like you, but I have been fine just running the entire job on the digital. I might run a 10K sheet VD job. Can you duplex on your machine? What software do you use for VD, and what is your RIP? If you can duplex the stock your running the VD on, there's no reason why you couldn't do it all on your digital machine. If the job needs to stay in order you'll have to keep a close eye on it during printing and finishing, but it might save you the headaches of going from offset to digital, with all the curl and powder issues. This is of course, if it is mainly color. FOr black you may want to run shells and use powder at a minimum.