There were huge differences between pos/neg with conventional plates - such as the impact of dust... (much more likely to result in a spot on a pos plate than a neg plate, due to ink coverage averages). In the digital world, you have to look a bit further than just the pos/neg aspect, and see what each plate system offers.
No clamp shadow, as mentioned above, is a benefit for some - especially if you have a press with narrow gripper margins on the plate, or if you image your plates rotated compared to how they go on press (for faster throughput, etc.). It can also speed up imaging if you don't have to expose the full plate (which isn't possible on pos plates).
Negative plates tend to give you some benefits on processing chemistry too. Negative chemical systems often are not sensitive to air exposure, reducing the anti-ox replenishment usage and extending the life of the bath. They can also have lower pH, and lower overall replenishment - but that varies from system to system.
Our new Trillian SP plate is a negative-working plate, and has significant chemical benefits as mentioned above (pH-neutral, very low chemical usage, etc.).
However, in the digital world, it's not always so clear cut. Even our positive-working Sword Excel plate uses a "negative-type" developer, with the pH and anti-ox benefits noted above. You have to compare each plate system against your business and environmental needs, instead of generalizing on pos/neg.
Kevin.