I think you have problem with Piling in your case. Probably in these case you miss some details or you have empty place on a print. Is it showing with inks printed at first in your color order?
Some causes may be wrong fountain solution,printing blankets too tacky or wrong paper coating.You should Treat blanket or change to less tacky blanket,check fountain solution, it could be a lot of things when speaking of piling so you can find more info here.