My experience from prepress has been that hyrbids are the absolute worst of both worlds. We have a CD102 setup with all of the fancy hybrid rollers, isolated press washes, etc. and we run spot colors with almost every job UV/conventional/hybrid depending on the job. The hybrid jobs are the ones that cause the most grief in printing, prepress and quality control. We've tried 3 different ink vendors and experienced the same problems.I have found running hybrid UV inks much easier than running full UV inks.