So, for example on a 10 color you allow 800 make ready sheets? I would consider that excessive on a late model fully auto press. Generally, (our presses are not auto, semi auto plate loading only, and manual profiling) we take one pull for rego, and 2 run downs of 100 sheets to ensure profile is correct and stable. More sheets are sometimes required if you have to chase down marking etc, so hopefully a few runners are on hand.
This is purely job related, some jobs we start running at slow speed and can pretty much flick on the counter after 100 sheets and fine tune as you run.
Edit:
there is also an old rule that applies; the more overs you have = less problems encountered