I used to be against JPEG as well, but several years ago (after reading Gordo's tests), I started using it (Max quality though) and have had no problems.Going from memory (I guess I tossed the Pressready preset) the main differences are that PDF/X-4 requires an output intent, requires that fonts be embedded, and sets the compatibility to PDF 1.6 because transparency is allowed. Everything else can be adjusted by the user.
PDF/X-4 doesn't seem to be all that "popular", yet, but I recommend it. Having an output intent and live transparency can be very useful to those in prepress.
Something that I strongly dislike about the Pressready preset is that it uses JPEG compression, which I council against for print. I don't advise using JPEG2000 or Run Length, either, because of a lack of support in RIPs. ZIP, LZW, and CCITT are all safe choices, in my experience.
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